This article takes the rotor shaft of the GE1000T internal mixer as an example, dissecting the external structure, machining characteristics, dimensions, and geometric elements of the part, and carrying out the design of the overall process flow. It focuses on the design of the finishing process on the turning and milling compound equipment, comprehensively analyzing the semi-finishing turning reserved blank, positioning clamping, tool selection, machining parameters, tool path trajectory, the use of center frame and tip attachment, NC code, and other contents. The optimization design of each step in the turning and milling compound finishing process is carried out, especially focusing on the difficulties encountered during the machining process, such as the control of finishing turning dimensions and roughness, deep hole drilling methods, etc. At the same time, the exploration of the MAZAK E670H 6000U equipment and ESPRIT software, as well as the method of combining software and hardware, is conducted.